Wollina U, Schaarschmidt H, Henkel U, Knopf B, Hipler C
Universitäts-Hautklinik Jena, Friedrich-Schiller-Universität.
Z Hautkr. 1989 Aug 15;64(8):694-6, 699.
Dermal nevocytic nevi (NN) were histochemically studied with the help of FITC-conjugated lectins as well as antisera against keratin and plasminogen activators of the urokinase type. 3 out of 18 NN showed interpenetrating nevus cells in atrophic parts of the epidermis. These cells revealed strong lectin reactivity both with Con A (cytoplasmatic binding) and WGA/RCA II (membraneous binding). In addition we found membraneous reaction with anti-urokinase, whereas there was no anti-keratin staining. Our findings suggest active transepidermal elimination of nevus cells in dermal nevocytic nevi.
利用异硫氰酸荧光素（FITC）偶联的凝集素以及抗角蛋白和尿激酶型纤溶酶原激活剂的抗血清，对皮肤痣细胞痣（NN）进行了组织化学研究。18例NN中有3例在表皮萎缩部位出现相互交错的痣细胞。这些细胞与刀豆球蛋白A（Con A，胞质结合）和小麦胚芽凝集素/蓖麻凝集素II（WGA/RCA II，膜结合）均显示出强烈的凝集素反应性。此外，我们发现其与抗尿激酶有膜反应，而无抗角蛋白染色。我们的研究结果提示，皮肤痣细胞痣中存在痣细胞的主动经表皮清除现象。
