Eigler Tamar, Ben-Shlomo Anat
Division of EndocrinologyDiabetes and Metabolism, Department of Medicine, Pituitary Center, Cedars Sinai Medical Center, Davis Building, Room 3066, 8700 Beverly Boulevard, Los Angeles, California 90048, USA.
Division of EndocrinologyDiabetes and Metabolism, Department of Medicine, Pituitary Center, Cedars Sinai Medical Center, Davis Building, Room 3066, 8700 Beverly Boulevard, Los Angeles, California 90048, USA
J Mol Endocrinol. 2014 Aug;53(1):R1-19. doi: 10.1530/JME-14-0034. Epub 2014 Apr 29.
The somatostatin (SRIF) system, which includes the SRIF ligand and receptors, regulates anterior pituitary gland function, mainly inhibiting hormone secretion and to some extent pituitary tumor cell growth. SRIF-14 via its cognate G-protein-coupled receptors (subtypes 1-5) activates multiple cellular signaling pathways including adenylate cyclase/cAMP, MAPK, ion channel-dependent pathways, and others. In addition, recent data have suggested SRIF-independent constitutive SRIF receptor activity responsible for GH and ACTH inhibition in vitro. This review summarizes current knowledge on ligand-dependent and independent SRIF receptor molecular and functional effects on hormone-secreting cells in the anterior pituitary gland.
生长抑素（SRIF）系统包括SRIF配体和受体，可调节垂体前叶功能，主要抑制激素分泌，并在一定程度上抑制垂体肿瘤细胞生长。SRIF-14通过其同源G蛋白偶联受体（亚型1-5）激活多种细胞信号通路，包括腺苷酸环化酶/cAMP、丝裂原活化蛋白激酶（MAPK）、离子通道依赖性通路等。此外，最近的数据表明，在体外，生长激素（GH）和促肾上腺皮质激素（ACTH）的抑制作用与SRIF无关，而是由SRIF受体的组成性活性介导。本文综述了目前关于SRIF受体对垂体前叶激素分泌细胞的配体依赖性和非依赖性分子及功能影响的研究进展。
