用于临床应用的未成熟人类卵母细胞的体外成熟培养
In vitro maturation of immature human oocytes for clinical application.
作者信息
Chian Ri-Cheng, Cao Yun-Xia
机构信息
Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital, Women's Pavilion F3, 687 Pine Avenue West, Montreal, Quebec, Canada, H3A 1A1,
出版信息
Methods Mol Biol. 2014;1154:271-88. doi: 10.1007/978-1-4939-0659-8_12.
Meiotic progression in the oocyte is defined as oocyte maturation from reinitiation of the first meiotic division from the germinal vesicle (GV) stage to the metaphase-II (M-II) stage (Fig. 1), (Cha and Chian, Hum Reprod Update 4:103-120, 1998). Priming with FSH or HCG prior to immature oocyte retrieval improves oocyte maturation and pregnancy rates. The size of follicles may be an important feature for IVM treatment. The combination of natural-cycle IVF with immature oocyte retrieval followed by IVM is an attractive treatment for young women with all types of infertility without recourse to ovarian stimulation with an acceptable pregnancy rate.
卵母细胞的减数分裂进程被定义为从生发泡（GV）期重新启动第一次减数分裂到中期-II（M-II）期的卵母细胞成熟过程（图1），（查和钱，《人类生殖更新》4:103 - 120，1998年）。在未成熟卵母细胞采集前用促卵泡激素（FSH）或人绒毛膜促性腺激素（HCG）预处理可提高卵母细胞成熟率和妊娠率。卵泡大小可能是体外成熟（IVM）治疗的一个重要特征。自然周期体外受精（IVF）联合未成熟卵母细胞采集及后续的IVM，对于所有类型不孕的年轻女性来说，是一种有吸引力的治疗方法，无需进行卵巢刺激且妊娠率可接受。
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