Reproductive Medicine Center, Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.
Reproductive Medicine Center, Department of Gynecology and Obstetrics, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Avenue, Wuhan, 430014, China.
Reprod Sci. 2022 Aug;29(8):2127-2135. doi: 10.1007/s43032-021-00613-3. Epub 2021 Jun 2.
Oocyte in vitro maturation (IVM) is a technology with a long history that was established before IVF. Although it has been studied extensively, the efficiency of IVM has been poor for almost 30 years. In terms of the benefits of IVM, the efficiency and adoption of IVM are being improved by some notable improvements that have occurred in recent years. The establishment of biphasic IVM is the most important advancement in recent years. Biphasic IVM includes the pre-IVM culturing phase and IVM phase. The CNP-mediated pre-IVM culturing system is specifically tailored for non/minimally stimulated immature oocytes, and its efficiency has been shown. This is the most significant improvement made in recent decades in this area. In the clinic, IVM can be used for PCOS patients to avoid the occurrence of ovarian hyperstimulation syndrome (OHSS). Additionally, this method can solve the reproductive problems of some patients with special diseases (resistant ovary syndrome) that cannot be solved by IVF. In most fertility preservation procedures, oocytes in small antral follicles are lost. However, IVM has the ability to capture this kind of oocyte and save reproductive potential. IVM can be easily combined with fertility preservation strategies that have been applied in the clinic and improve the efficiency of fertility preservation. IVM is a useful and attractive technology and may be used widely worldwide in the near future.
卵母细胞体外成熟（IVM）是一项历史悠久的技术，早在 IVF 之前就已建立。尽管已经进行了广泛的研究，但近 30 年来 IVM 的效率一直很差。就 IVM 的益处而言，近年来发生的一些显著改进正在提高 IVM 的效率和采用率。双相 IVM 的建立是近年来最重要的进展。双相 IVM 包括预 IVM 培养阶段和 IVM 阶段。CNP 介导的预 IVM 培养系统是专门为非/最小刺激不成熟卵母细胞设计的，其效率已经得到了证明。这是该领域近几十年来最重要的改进。在临床上，IVM 可用于 PCOS 患者，以避免卵巢过度刺激综合征（OHSS）的发生。此外，这种方法可以解决一些特殊疾病（耐药卵巢综合征）患者无法通过 IVF 解决的生殖问题。在大多数生育力保存程序中，小窦卵泡中的卵母细胞都会丢失。然而，IVM 能够捕获这种卵母细胞并保存生殖潜能。IVM 可以很容易地与已经在临床上应用的生育力保存策略相结合，提高生育力保存的效率。IVM 是一项有用且有吸引力的技术，可能在不久的将来在全球范围内得到广泛应用。
