福图星的不对称合成及其绝对构型的重新确定。
Asymmetric synthesis of fortucine and reassignment of its absolute configuration.
作者信息
Beaulieu Marc-André, Ottenwaelder Xavier, Canesi Sylvain
机构信息
Département de chimie, Université du Québec à Montréal, Laboratoire de Méthodologie et Synthèse de Produits Naturels, C.P.8888, Succ. Centre-Ville, Montréal, QC, H3C 3P8 (Canada), Fax: (+1) 514-987-4054.
出版信息
Chemistry. 2014 Jun 16;20(25):7581-4. doi: 10.1002/chem.201402323. Epub 2014 Apr 29.
A convergent and enantioselective synthesis of fortucine was achieved from the starting materials tyrosine methyl ester and 3-hydroxy-4-methoxybenzaldehyde. The synthesis is based on two key steps mediated by a hypervalent iodine reagent. This work has enabled us to reassign the absolute configuration of the natural product reported in the literature.
以酪氨酸甲酯和3-羟基-4-甲氧基苯甲醛为起始原料，实现了福图辛的对映选择性汇聚合成。该合成基于高价碘试剂介导的两个关键步骤。这项工作使我们能够重新确定文献中报道的天然产物的绝对构型。
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