Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra ACT 0200, Australia.
Org Lett. 2010 Nov 19;12(22):5210-3. doi: 10.1021/ol102249q. Epub 2010 Oct 26.
The synthesis of the enantiomer of the structure, 1, assigned to the natural product nobilisitine A has been accomplished using the enantiomerically pure cis-1,2-dihydrocatechol 4 as starting material. The (1)H and (13)C NMR spectral data derived from compound ent-1 do not match those reported for the natural product, thus suggesting its structure has been incorrectly assigned.
使用对映体纯的顺式-1,2-二氢邻苯二酚 4 作为起始原料，完成了结构 1 的对映异构体的合成，该结构被分配给天然产物诺比利西汀 A。从化合物 ent-1 衍生出的 (1)H 和 (13)C NMR 谱数据与天然产物报道的数据不匹配，因此表明其结构的归属是错误的。
