采用纳米颗粒催化全合成（±）-索罗醇 B。
Total synthesis of (±)-sorocenol B employing nanoparticle catalysis.
机构信息
Department of Chemistry, Center for Chemical Methodology and Library Development (CMLD-BU), Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
出版信息
Org Lett. 2012 May 18;14(10):2516-9. doi: 10.1021/ol300800r. Epub 2012 May 3.
Abstract
The total synthesis of (±)-sorocenol B has been accomplished featuring key steps including silver nanoparticle (AgNP)-catalyzed Diels-Alder cycloaddition and late-stage Pd(II)-catalyzed oxidative cyclization. The synthetic natural product exhibited low micromolar cytotoxic activity against a number of human cancer cell lines.
摘要
（±）-索罗醇 B 的全合成已经完成，关键步骤包括银纳米粒子（AgNP）催化的 Diels-Alder 环加成反应和晚期的 Pd(II)催化的氧化环化反应。该合成天然产物对多种人癌细胞系表现出低微摩尔细胞毒性活性。
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