Lynch J J, Eskin T A, Merigan W H
Department of Biophysics, University of Rochester School of Medicine and Dentistry, NY 14642.
Brain Res. 1989 Oct 16;499(2):325-32. doi: 10.1016/0006-8993(89)90781-6.
Selective degeneration of retinal ganglion cells projecting to parvocellular layers of the dorsal lateral geniculate nucleus (LGN) was observed in squirrel monkeys (Saimiri sciureus) exposed to a range of doses of acrylamide monomer. Similar acrylamide-induced neuronal loss has previously been reported in parvocellular-projecting ganglion cells of macaques, but no such selective degeneration has been found in acrylamide-dosed rats, squirrels, rabbits or cats. The extent of ganglion cell loss observed in the present study suggests that in the squirrel monkey, as in the macaque, a majority of ganglion cells project to parvocellular layers of the LGN. The locus of optic tract degeneration suggests that the squirrel monkey parvocellular pathway passes in dorsolateral optic tract, as does that of the macaque. Patterns of decreases in cytochrome oxidase activity confirm that, in both of these primates, geniculocortical pathways driven by these vulnerable neurons project to cortical layers 4A and 4C beta. These results suggest close parallels in the neuroanatomical projections and toxic vulnerability of the parvocellular-projecting pathway in New and Old World monkeys. They indicate that acrylamide intoxication can be used to selectively damage this pathway in order to study the functional roles of parallel visual pathways in both New and Old World monkeys.
在暴露于一系列剂量丙烯酰胺单体的松鼠猴（Saimiri sciureus）中，观察到投射到背侧外侧膝状核（LGN）小细胞层的视网膜神经节细胞发生选择性退化。此前在猕猴的小细胞投射神经节细胞中也报道过类似的丙烯酰胺诱导的神经元丢失，但在给予丙烯酰胺的大鼠、松鼠、兔子或猫中未发现这种选择性退化。本研究中观察到的神经节细胞丢失程度表明，与猕猴一样，在松鼠猴中，大多数神经节细胞投射到LGN的小细胞层。视束退化的部位表明，松鼠猴的小细胞通路与猕猴一样，走行于背外侧视束。细胞色素氧化酶活性降低的模式证实，在这两种灵长类动物中，由这些易损神经元驱动的膝状皮质通路投射到皮质4A层和4Cβ层。这些结果表明，新旧世界猴中小细胞投射通路的神经解剖投射和毒性易感性存在密切相似之处。它们表明，丙烯酰胺中毒可用于选择性损伤该通路，以便研究新旧世界猴中平行视觉通路的功能作用。
