Musilová J, Michalová K, Folberová L, Pacovský V
Cas Lek Cesk. 1989 Sep 8;128(37):1166-9.
Phytohemagglutinin-stimulated lymphocytes from 20 young (16-28 years) and 20 old (70-88 years) healthy subjects have been investigated for chromosome aberrations before and after exposure to bleomycin in G2 phase of the cell cycle. No differences were found in unexposed cultures between young and old donors. After treatment with bleomycin the frequency of chromosome aberrations was significantly higher in the old subjects than in the young ones (p less than 0.05). The results suggest that the different interaction between the mutagen and DNA may be caused by the decreased capacity of the excision repair system in the cells of the old individuals.
对20名年轻（16 - 28岁）和20名老年（70 - 88岁）健康受试者的植物血凝素刺激淋巴细胞，在细胞周期的G2期暴露于博来霉素前后进行了染色体畸变研究。在未暴露的培养物中，年轻和老年供体之间未发现差异。用博来霉素处理后，老年受试者的染色体畸变频率显著高于年轻受试者（p小于0.05）。结果表明，诱变剂与DNA之间不同的相互作用可能是由老年个体细胞中切除修复系统能力下降所致。
