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一例多发性结节性甲状腺肿伴滤泡性腺瘤的无症状性 Riedel 甲状腺炎:一种不常见的关联。

A case of asymptomatic riedel thyroiditis with follicular adenoma in a patient with a multinodular goiter: an unusual association.

机构信息

Department of Pathology, Mustafa Kemal University Medical Faculty, Hatay, Turkey.

Department of Endocrinology and Metabolism, Mustafa Kemal University Medical Faculty, Hatay, Turkey.

出版信息

Eur Thyroid J. 2012 Oct;1(3):204-7. doi: 10.1159/000342628. Epub 2012 Sep 22.

Abstract

BACKGROUND

Riedel's thyroiditis (RT) is a rare inflammatory disease that results in fibrosis of the thyroid gland and invasion to the surrounding structures of the neck. Follicular adenoma (FA) of the thyroid is the most common benign neoplasm of the gland.

PATIENT FINDINGS

A 42-year-old woman was referred to the outpatient clinic due to a multinodular goiter and thyroiditis. The patient was euthyroid and thyroid function tests were within normal limits. Thyroid antibodies (thyroid peroxidase antibody and thyroglobulin antibody) were high. Thyroid ultrasonography showed multiple iso-hypoechoic nodules and thyroiditis. Fine-needle aspiration cytology was performed, and it was consistent with 'suspicious for a follicular neoplasm' according to the Bethesda system. Due to the clinical findings, which included weight loss and sweating, and the cytological results indicative of a follicular neoplasm, the patient underwent a total thyroidectomy. The histopathological diagnosis was RT associated with FA. The patient was started on thyroid hormone (thyroxine) replacement therapy after surgery and was evaluated for additional fibrosis related to RT.

CONCLUSIONS

To our knowledge, this is the first case of RT associated with FA in an asymptomatic patient with a multinodular goiter and high thyroid antibodies reported in the literature.

摘要

背景

Riedel 甲状腺炎(RT)是一种罕见的炎症性疾病,可导致甲状腺纤维化和颈部周围结构侵犯。甲状腺滤泡性腺瘤(FA)是最常见的甲状腺良性肿瘤。

病例特征

一名 42 岁女性因多结节性甲状腺肿和甲状腺炎就诊于门诊。患者甲状腺功能正常,甲状腺功能检查正常。甲状腺自身抗体(甲状腺过氧化物酶抗体和甲状腺球蛋白抗体)升高。甲状腺超声显示多个等低回声结节和甲状腺炎。行细针抽吸细胞学检查,根据 Bethesda 系统,结果符合“可疑滤泡性肿瘤”。鉴于该患者存在体重减轻和出汗等临床症状,以及细胞学结果提示滤泡性肿瘤,行甲状腺全切除术。组织病理学诊断为 RT 合并 FA。术后开始甲状腺激素(甲状腺素)替代治疗,并评估与 RT 相关的其他纤维化。

结论

据我们所知,这是首例无症状多结节性甲状腺肿和高甲状腺抗体患者的 RT 合并 FA 病例,该病例在文献中报道。

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