[Scleromyxedema without paraproteinemia].

The identification of an abnormal paraproteinaemia has been considered as main criterium for the diagnosis of scleromyxedema. We report a case of scleromyxedema in a 51-year old man, without any immunochemical evidence of paraprotein. Our case is a clinical support to the independence of this disease from gammopathy, as underlined by other experimental and clinical data. Thus demonstration of paraprotein should not be considered as a fundamental criterion for the diagnosis of scleromyxedema.