硬皮黏液水肿中单克隆副蛋白的免疫化学分析

Immunochemical analysis of the monoclonal paraprotein in scleromyxedema.

作者信息

Kitamura W, Matsuoka Y, Miyagawa S, Sakamoto K

出版信息

J Invest Dermatol. 1978 Jun;70(6):305-8. doi: 10.1111/1523-1747.ep12543468.

Abstract

The monoclonal paraprotein from a typical case of scleromyxedema was isolated and characterized. The isolated paraprotein was of the IgG-lambda class, with a molecular weight of approximately 110,000 daltons compared with 160,000 daltons for normal IgG. Immunochemical studies indicated that the paraprotein was an incomplete IgG molecule which was missing a significant antigenic portion of the Fd fragment.

摘要

从硬皮病黏液水肿典型病例中分离并鉴定出单克隆副蛋白。分离出的副蛋白属于IgG-λ类，分子量约为110,000道尔顿，而正常IgG的分子量为160,000道尔顿。免疫化学研究表明，该副蛋白是一个不完整的IgG分子，缺少Fd片段的一个重要抗原部分。