Wan Yisong Y
Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA.
Trends Immunol. 2014 Jun;35(6):233-42. doi: 10.1016/j.it.2014.04.002. Epub 2014 Apr 28.
GATA3 has conventionally been regarded as a transcription factor that drives the differentiation of T helper (Th) 2 cells. Increasing evidence points to a function for GATA3 beyond controlling Th2 differentiation. GATA3 regulates T cell development, proliferation, and maintenance. Furthermore, recent studies have demonstrated important roles for GATA3 in innate lymphoid cells. Thus, GATA3 emerges as a factor with diverse functions in immune regulation, which are in some cases cell-type specific and in others shared by multiple cell types. Here, I discuss recent discoveries and the current understanding of the functions of GATA3 in immune regulation.
传统上，GATA3被认为是一种驱动辅助性T（Th）2细胞分化的转录因子。越来越多的证据表明，GATA3的功能不止于控制Th2细胞分化。GATA3可调节T细胞的发育、增殖和维持。此外，最近的研究表明GATA3在固有淋巴细胞中也发挥着重要作用。因此，GATA3成为一种在免疫调节中具有多种功能的因子，这些功能在某些情况下具有细胞类型特异性，而在其他情况下则为多种细胞类型所共有。在此，我将讨论GATA3在免疫调节功能方面的最新发现和当前认识。
