Watanabe H
Department of Orthopaedic Surgery, St. Marianna University School of Medicine, Kanagawa, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1989 Aug;63(8):800-9.
Sixty two cases of schwannoma were studied immunohistochemically and ultrastructurally for further understanding of the histogenesis of Antoni B area. For immunohistochemical study, the author used the antibodies against fibronectin (FN), factor XIIIa (XIIIa), and collagen type I and III. FN and XIIIa were positive with a fibrillar pattern in Antoni B area. Collagen type I and III were positive in the extracellular matrix of Antoni B area, but not in Antoni A area. Ultrastructurally, Antoni B area consisted of degenerative Schwann cells and fibroblasts. These findings closely resemble those of fibrogenesis seen in the wound healing process or in the stroma around tumor. The author concluded that the fibrogenesis occurring in Antoni B area reflects the stromal reaction against Antoni A area, in contrast to the previous studies that Antoni B area only represents degenerative change of Antoni A area.
对62例神经鞘瘤进行了免疫组织化学和超微结构研究，以进一步了解Antoni B区的组织发生。免疫组织化学研究中，作者使用了抗纤连蛋白（FN）、因子XIIIa（XIIIa）以及I型和III型胶原的抗体。FN和XIIIa在Antoni B区呈阳性，呈纤维状模式。I型和III型胶原在Antoni B区的细胞外基质中呈阳性，但在Antoni A区不呈阳性。超微结构上，Antoni B区由退变的施万细胞和成纤维细胞组成。这些发现与伤口愈合过程或肿瘤周围基质中所见的纤维生成非常相似。作者得出结论，Antoni B区发生的纤维生成反映了对Antoni A区的基质反应，这与之前认为Antoni B区仅代表Antoni A区退变变化的研究相反。
