Wang Lu, Cao Wei, Yi Yu, Xu Huaping
Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University , Beijing 100084, People's Republic of China.
Langmuir. 2014 May 20;30(19):5628-36. doi: 10.1021/la501054z. Epub 2014 May 9.
A general approach is reported to fabricate a stimuli responsive system via coassembly of diselenide-containing block copolymers with polymer lipids, which integrates the stimuli-responsiveness of diselenide chemistry and the biocompatibility of polymer lipids. By using dynamic light scattering, transmission electron microscopy, and zeta potential analyzer, coassembly behavior of these two kinds of polymers and responsiveness of coassemblies have been investigated. These coassemblies can exhibit redox-responsiveness inheriting from the diselenide-containing block copolymers. In the presence of low concentration of hydrogen peroxide or glutathione, the coassemblies can be disrupted.
据报道，一种通用方法是通过含二硒化物的嵌段共聚物与聚合物脂质的共组装来构建刺激响应系统，该系统整合了二硒化物化学的刺激响应性和聚合物脂质的生物相容性。通过动态光散射、透射电子显微镜和zeta电位分析仪，研究了这两种聚合物的共组装行为以及共组装体的响应性。这些共组装体可表现出来自含二硒化物嵌段共聚物的氧化还原响应性。在低浓度过氧化氢或谷胱甘肽存在下，共组装体可被破坏。
