Yang Yanjun, Sun Wen
State Key Laboratory of Fine Chemicals, Dalian University of Technology Dalian 116024 China
Ningbo Institute of Dalian University of Technology Ningbo 315016 China.
Nanoscale Adv. 2022 Jul 28;4(17):3504-3516. doi: 10.1039/d2na00222a. eCollection 2022 Aug 23.
The combination of multiple therapeutic modalities has attracted increasing attention as it can achieve better therapeutic effects through different treatment mechanisms. However, traditional small molecule agents are non-specific to the tumor tissue, which leads to off-target toxic effects for healthy tissues. To solve this problem, a number of stimuli-responsive nanoscale drug-delivery systems have been developed. Among these stimuli, a high concentration of reactive oxygen species (ROS) and glutathione (GSH) are characteristic of the tumor microenvironment (TME), which can distinguish it from normal tissue. In this review, we summarize the redox-responsive nanoparticles (NPs) reported in the past three years classified by different functional groups, including GSH-responsive disulfide, ditelluride, and multivalent metal ions, ROS-responsive thioketal, arylboronic ester, aminoacrylate, and bilirubin as well as GSH/ROS dual-responsive diselenide and dicarbonyl thioethers. The prospects and challenges of redox-responsive NPs are also discussed.
多种治疗方式的联合应用因其能通过不同的治疗机制实现更好的治疗效果而受到越来越多的关注。然而，传统小分子药物对肿瘤组织缺乏特异性，这会对健康组织产生脱靶毒性作用。为了解决这个问题，人们开发了许多刺激响应性纳米级药物递送系统。在这些刺激因素中，高浓度的活性氧（ROS）和谷胱甘肽（GSH）是肿瘤微环境（TME）的特征，这使其有别于正常组织。在本综述中，我们总结了过去三年报道的按不同官能团分类的氧化还原响应性纳米颗粒（NP），包括GSH响应性二硫键、二碲化物和多价金属离子、ROS响应性硫代缩酮、芳基硼酸酯、氨基丙烯酸酯和胆红素，以及GSH/ROS双响应性二硒化物和二羰基硫醚。还讨论了氧化还原响应性NP的前景和挑战。
