[Postoperative changes in amount of granulocyte-elastase, alpha 1-antitrypsin and other acute phase reactants in blood in obstetrical and gynecological patients].

Postoperative changes in acute phase reactants (APR) upon administration of latamoxef (LMOX) were studied in 43 patients who underwent laparotomy (total hysterectomy, cesarean section or resection of ovarian tumor). The results obtained are summarized as follows. 1. Postoperative changes in APR, i.e., amount of granulocyte-elastase, alpha 1-antitrypsin (alpha 1-AT), alpha 1-acid glycoprotein, haptoglobin and CRP, in the maternal blood were determined. These 5 markers increased and tended to decrease at 7 days and 14 days after surgery, respectively, in the total hysterectomy group. The vital defense response to surgical invasion and the reaction occurring during the process of recovery show that changes in level of granulocyte-elastase, alpha 1-AT and CRP immediately reflect the resulting inflammatory reaction. The changes in elastase and alpha 1-AT levels upon cesarean section showed a similar tendency, but levels of these markers were high as a whole during pregnancy and postpartum. 2. There were no postoperative complications or subjective or objective side effects of the LMOX treatment in any of the studied patients, suggesting that LMOX is useful for the prevention of postoperative infection.