Ito H, Ito M, Mitsuhata N, Tahara E
Department of Pathology, Hiroshima University School of Medicine.
Jpn J Clin Oncol. 1989 Sep;19(3):299-304.
A case of prostatic phyllodes tumor which developed in a 78-yr-old man is reported. Histologically, the tumor comprised myxomatous and cellular portions with a proliferation of atypical stromal cells. Multinucleated giant cells were occasionally present, but mitoses were rare. Fibroblastic differentiation of the tumor cells was confirmed by numerous rough endoplasmic reticulums and free ribosomes, and by immunoreactivity for vimentin. Approximately one-third of the tumor cells showed estrogen-receptor immunoreactivity at their nuclei. The patient is well, with no evidence of tumor recurrence, five years after the resection. The tumor was diagnosed as being a benign prostatic phyllodes tumor showing fibroblastic differentiation, and of an estrogen-dependent nature.
报道了一例发生在一名78岁男性身上的前列腺叶状肿瘤。组织学上，肿瘤由黏液样和细胞性部分组成，伴有非典型基质细胞增殖。偶尔可见多核巨细胞，但有丝分裂罕见。肿瘤细胞的成纤维细胞分化通过大量粗面内质网和游离核糖体以及波形蛋白免疫反应性得以证实。大约三分之一的肿瘤细胞核显示雌激素受体免疫反应性。患者在切除术后五年情况良好，无肿瘤复发迹象。该肿瘤被诊断为具有成纤维细胞分化且依赖雌激素的良性前列腺叶状肿瘤。
