van Meel J C, Diederen W
Division of Cardiovascular Pharmacology, Dr. Karl Thomae GmbH, Biberach/Riss, F.R.G.
J Cardiovasc Pharmacol. 1989;14 Suppl 2:S1-6.
Pimobendan (UD-CG 115 BS) is a potent positive inotropic agent with vasodilatory properties. This hemodynamic profile was demonstrated in conscious rabbits chronically instrumented with Doppler flow probes. Pimobendan (10, 30, 100, and 300 micrograms/kg i.v.) increased cardiac output, stroke volume, heart rate, and mesenteric, renal, and hindquarter blood flow velocities, and decreased diastolic blood pressure. The positive inotropic effects of pimobendan and its effects on pre- and afterload were also shown in dogs with propranolol-induced depressed myocardial function. Pimobendan exhibited strong effects on stroke volume (up to 59%) and pulmonary capillary wedge pressure (up to -84%). The substance increased left ventricular (LV) dp/dtmax up to 150% and also had favorable effects on renal blood flow. Left ventricular function curves showed the usefulness of pimobendan in this acute heart failure model. Pimobendan is well absorbed and its duration of action is long. Positive inotropic effects of pimobendan were observed for 8-12 h after oral administration of 0.1-1 mg/kg to conscious dogs. It is concluded that pimobendan produces cardiovascular effects that may be useful in the treatment of congestive heart failure.
匹莫苯丹（UD-CG 115 BS）是一种具有血管舒张特性的强效正性肌力药物。这种血流动力学特征在长期植入多普勒血流探头的清醒家兔身上得到了证实。匹莫苯丹（静脉注射剂量为10、30、100和300微克/千克）可增加心输出量、每搏输出量、心率以及肠系膜、肾和后肢的血流速度，并降低舒张压。在普萘洛尔诱导心肌功能抑制的犬类身上，也显示了匹莫苯丹的正性肌力作用及其对前负荷和后负荷的影响。匹莫苯丹对每搏输出量（高达59%）和肺毛细血管楔压（高达 -84%）有显著作用。该物质可使左心室（LV）dp/dtmax增加高达150%，并且对肾血流量也有有利影响。左心室功能曲线表明匹莫苯丹在这种急性心力衰竭模型中是有用的。匹莫苯丹吸收良好且作用持续时间长。给清醒犬口服0.1 - 1毫克/千克后，在8 - 12小时内观察到匹莫苯丹的正性肌力作用。结论是匹莫苯丹产生的心血管效应可能对充血性心力衰竭的治疗有用。
