Sández Ignacio, Redondo José I, Donati Pablo A, Gómez José
Department of Anesthesiology and Pain Management, Hospital Veterinario AniCura-Vetsia, Leganés, 28914 Madrid, Spain.
Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain.
Animals (Basel). 2023 Jun 26;13(13):2110. doi: 10.3390/ani13132110.
Pimobendan is an inotropic and vasodilator drug with no sympathomimetic effects. This study aimed to evaluate the haemodynamic effects of pimobendan during anaesthesia in healthy senior dogs. A prospective, randomised, triple-blinded, placebo-controlled clinical study was conducted. Thirty-three dogs (median [range]: 9 [7, 12] years) were anaesthetised for surgical procedures. The dogs were randomly allocated into two groups: eighteen dogs received intravenous pimobendan at a dose of 0.15 mg/kg (PIMOBENDAN), and fifteen dogs received intravenous saline solutions at a dose of 0.2 mL/kg (PLACEBO). Data were recorded before, 1 min, 10 min, and 20 min after injection. Velocity-time integral (VTI), peak-velocity (PV), and mean-acceleration (MA) were measured using an oesophageal Doppler monitor (ODM). Heart rate and mean arterial pressure were also registered. The data were analysed using a two-way ANOVA for trimmed means. Statistical differences were considered if p < 0.05. Twenty minutes after injection, the VTI (13.0 cm [10.4, 22.3]), PV (95.0 [83.0, 160] m/s), and MA (12.6 [9.40, 17.0] m/s) were significantly higher in the PIMOBENDAN group compared to the PLACEBO group (VTI: 10.5 [6.50, 17.4] cm, PV: 80.0 [62.0, 103] m/s and MA: 10.2 [7.00, 16.0] ms). No significant differences were observed in the rest of the variables. Using pimobendan during anaesthesia increases VTI, PV, and MA, as measured by an ODM.
匹莫苯丹是一种无拟交感神经作用的强心和血管扩张药物。本研究旨在评估匹莫苯丹在健康老龄犬麻醉期间的血流动力学效应。进行了一项前瞻性、随机、三盲、安慰剂对照的临床研究。33只犬（中位数[范围]：9[7,12]岁）接受麻醉以进行外科手术。这些犬被随机分为两组：18只犬静脉注射0.15mg/kg的匹莫苯丹（匹莫苯丹组），15只犬静脉注射0.2mL/kg的生理盐水溶液（安慰剂组）。在注射前、注射后1分钟、10分钟和20分钟记录数据。使用食管多普勒监测仪（ODM）测量速度时间积分（VTI）、峰值速度（PV）和平均加速度（MA）。还记录心率和平均动脉压。使用双向方差分析对截尾均值进行数据分析。如果p<0.05，则认为存在统计学差异。注射后20分钟，匹莫苯丹组的VTI（13.0cm[10.4,22.3]）、PV（95.0[83.0,160]m/s）和MA（12.6[9.40,17.0]m/s）显著高于安慰剂组（VTI：10.5[6.50,17.4]cm，PV：80.0[62.0,103]m/s，MA：10.2[7.00,16.0]m/s）。其余变量未观察到显著差异。麻醉期间使用匹莫苯丹可增加通过ODM测量的VTI、PV和MA。
