Am J Psychiatry. 2014 May;171(5):499-505. doi: 10.1176/appi.ajp.2013.13101373.
Prevention of major depressive disorder is important because current treatments are only partially adequate in reducing symptom burden and promoting health-related quality of life. Lifestyle interventions may be a desirable prevention strategy for reasons of patient preference, particularly among older patients from minority groups. Using evidence from a randomized depression prevention trial for older adults, the authors found that coaching in healthy dietary practices was potentially effective in protecting at-risk older adults from developing incident episodes of major depression. The authors describe the dietary coaching program (highlighted in a case example) as well as the feasibility and potential efficacy of the program within the context of evidence-based interventions for preventing episodes of major depression and mitigating symptoms of depression. Older adults receiving dietary coaching experienced a low incidence of major depressive episodes and exhibited a 40%-50% decrease in depressive symptoms, as well as enhanced well-being, during the initial 6-week intervention; these gains were sustained over 2 years. The authors also describe why lifestyle interventions like coaching in healthy dietary practices may hold promise as effective, practical, nonstigmatizing interventions for preventing episodes of major depressive disorder in older adults with subsyndromal depressive symptoms.
预防重度抑郁症很重要,因为目前的治疗方法仅能部分缓解症状负担,促进健康相关的生活质量。基于患者偏好的原因,生活方式干预可能是一种理想的预防策略,尤其是对于来自少数群体的老年患者。作者利用一项针对老年人的随机抑郁预防试验的证据发现,健康饮食实践的指导在保护有患病风险的老年人免受重度抑郁发作方面具有潜在效果。作者描述了饮食指导计划(在案例中突出显示),以及该计划在预防重度抑郁发作和减轻抑郁症状的基于证据的干预措施背景下的可行性和潜在功效。接受饮食指导的老年人在重度抑郁发作方面的发生率较低,在最初的 6 周干预期间,抑郁症状减轻了 40%-50%,幸福感增强;这些收益在 2 年内得以维持。作者还描述了为什么像健康饮食实践指导这样的生活方式干预可能具有潜力,成为一种有效、实用、非污名化的干预措施,用于预防有亚临床抑郁症状的老年人大度抑郁发作。