Saffar Mohammad Jafar, Ghorbani Gholamreza, Hashemi Ahmad, Rezai Mohammad Sadegh
Pediatric Infectious Diseases Unit, Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran.
Indian J Pediatr. 2014 Dec;81(12):1332-6. doi: 10.1007/s12098-014-1445-0. Epub 2014 May 2.
To describe the epidemiological characteristics of pertussis cases reported to Mazandaran Center for Diseases Control and Prevention (P-CDC) during the years 2008-2011 in Mazandaran, North of Iran.
The patients included were those who fulfilled the WHO definition for pertussis or those clinically diagnosed by physicians. The demographic features of cases, their vaccination status, the incidence rate per 100,000 population, the relative proportion of cases for each age group, and their relation to vaccination status of the patients were all determined.
During the study period, a total of 518 cases of pertussis were reported; of which 43 were confirmed. The highest incidence rate and the largest proportion were 135.5 cases/100,000 and 37.7 %, respectively, observed in infants <12 mo of age. Almost 35.7 % of the cases were under vaccinated, however 54.4 % of them were fully vaccinated.
Pertussis infection has re-emerged in Mazandaran. It has caused a significant health problem in the susceptible young infants, and also among completely vaccinated children. Implementing strategies to protect these vulnerable infants and studies to evaluate the immunogenicity and efficacy of pertussis vaccine in Iran is recommended. It was difficult to confirm pertussis in the majority of cases, therefore, providing and improving laboratory diagnostic methods seems to be an urgent requirement.
描述2008 - 2011年期间伊朗北部马赞德兰省向马赞德兰疾病控制与预防中心（P - CDC）报告的百日咳病例的流行病学特征。
纳入的患者为符合世界卫生组织百日咳定义的患者或经医生临床诊断的患者。确定病例的人口统计学特征、疫苗接种状况、每10万人口的发病率、各年龄组病例的相对比例以及它们与患者疫苗接种状况的关系。
在研究期间，共报告了518例百日咳病例；其中43例得到确诊。发病率最高和比例最大的分别是12个月龄以下婴儿，发病率为135.5例/10万，占比37.7%。几乎35.7%的病例疫苗接种不足，然而其中54.4%的病例已全程接种疫苗。
百日咳感染在马赞德兰省再度出现。它在易感的幼儿以及全程接种疫苗的儿童中都引发了严重的健康问题。建议实施保护这些脆弱婴儿的策略，并开展研究以评估伊朗百日咳疫苗的免疫原性和效力。由于大多数病例难以确诊百日咳，因此提供并改进实验室诊断方法似乎是当务之急。
