Department of Infectious Diseases, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
BMC Neurol. 2022 Mar 1;22(1):70. doi: 10.1186/s12883-022-02606-4.
Multiple sclerosis (MS) is one of the most common neurological disorders which main cause is not identified yet. Some studies mentioned the possible role of infectious agents such as chlamydia pneumonia, mycoplasma and also, B. pertussis via asymptomatic nasopharyngeal colonization. The current study aimed to investigate and compared the serum level of B. pertussis antibody and the rate of nasopharyngeal colonization by this pathogen in subjects with and without MS.
In this case-control study, 109 patients with MS and 114 subjects without MS referred to Sina Hospital in Hamadan in 2019 are studied and compared in terms of serum titer of B. pertussis antibody and nasopharyngeal colonization by this bacterium. Colonization was evaluated using culture and real-time PCR techniques. Data were analyzed using SPSS version 16 with a 95% confidence interval.
The serum titer of B. pertussis antibody in case and control groups was 37.8 and 35.1%, respectively (P = 0.74). Culture and real-time PCR techniques revealed no case of nasopharyngeal colonization by B. pertussis.
There was no difference between B. pertussis antibody titer and the rate of nasopharyngeal colonization between both MS patients and the healthy control group. Therefore, it seems that probably B. pertussis has not a role in MS development.
多发性硬化症（MS）是最常见的神经紊乱疾病之一，其主要病因尚未确定。一些研究提到了感染因子的可能作用，如肺炎衣原体、支原体，以及通过无症状鼻咽部定植的百日咳博德特氏菌。本研究旨在调查和比较 MS 患者和无 MS 患者的血清百日咳博德特氏菌抗体水平和鼻咽部定植率。
在这项病例对照研究中，研究了 2019 年在哈马丹的 Sina 医院就诊的 109 名 MS 患者和 114 名无 MS 患者，比较了他们血清百日咳博德特氏菌抗体滴度和鼻咽部定植率。采用培养和实时 PCR 技术评估定植。使用 SPSS 版本 16 进行数据分析，置信区间为 95%。
病例组和对照组的百日咳博德特氏菌抗体血清滴度分别为 37.8%和 35.1%（P=0.74）。培养和实时 PCR 技术均未发现鼻咽部定植百日咳博德特氏菌。
MS 患者和健康对照组的百日咳博德特氏菌抗体滴度和鼻咽部定植率无差异。因此，百日咳博德特氏菌可能在 MS 发病机制中不起作用。
