Skaaby Tea, Husemoen Lise Lotte Nystrup, Thuesen Betina Heinsbæk, Pisinger Charlotta, Jørgensen Torben, Roswall Nina, Larsen Sofus Christian, Linneberg Allan
Authors' Affiliations: Research Centre for Prevention and Health and
Authors' Affiliations: Research Centre for Prevention and Health and.
Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1220-9. doi: 10.1158/1055-9965.EPI-14-0007. Epub 2014 Apr 30.
Observational studies have suggested an inverse association between vitamin D status and cancer. We investigated the prospective associations between vitamin D status and the total and specific type of cancer in three cohorts from the general Danish population.
A total of 12,204 individuals 18 to 71 years old were included. The level of 25-hydroxyvitamin D was measured at baseline, and information about cancer was obtained from the Danish Cancer Registry.
During the 11.3-year median follow-up time, there were 1,248 incident cancers. HRs [95% confidence intervals (CI)] per 10 nmol/L higher baseline vitamin D level were: for all cancers (HR = 1.02; 95% CI, 0.99-1.04), all cancers excluding non-melanoma skin cancer, NMSC (HR = 1.00; 95% CI, 0.97-1.03), head and neck cancer (HR = 0.97; 95% CI, 0.84-1.12), colorectal cancer (HR = 0.95; 95% CI, 0.88-1.02), cancer of bronchus and lung (HR = 0.98; 95% CI, 0.91-1.05), breast cancer (HR = 1.02; 95% CI, 0.96-1.09), cancer of the uterus (HR = 1.10; 95% CI, 0.95-1.27), prostate cancer (HR = 1.00; 95% CI, 0.93-1.08), cancer of the urinary organs (HR = 1.01; 95% CI, 0.90-1.14), NMSC (HR = 1.06; 95% CI, 1.02-1.10), and malignant melanoma (HR = 1.06; 95% CI, 0.95-1.17).
Apart from a significantly higher risk for NMSC with higher vitamin D status, we found no statistically significant associations between vitamin D status and total or specific cancers.
Our results do not indicate that there is an impact of vitamin D on total cancer incidence.
观察性研究表明维生素D水平与癌症之间存在负相关。我们在丹麦普通人群的三个队列中调查了维生素D水平与总体癌症及特定类型癌症之间的前瞻性关联。
共纳入12204名年龄在18至71岁之间的个体。在基线时测量25-羟基维生素D水平，并从丹麦癌症登记处获取癌症信息。
在11.3年的中位随访期内，有1248例新发癌症病例。基线维生素D水平每升高10 nmol/L的风险比[95%置信区间（CI）]为：所有癌症（风险比=1.02；95%CI，0.99-1.04），排除非黑色素瘤皮肤癌（NMSC）后的所有癌症（风险比=1.00；95%CI，0.97-1.03），头颈癌（风险比=0.97；95%CI，0.84-1.12），结直肠癌（风险比=0.95；95%CI，0.88-1.02），支气管和肺癌（风险比=0.98；95%CI，0.91-1.05），乳腺癌（风险比=1.02；95%CI，0.96-1.09），子宫癌（风险比=1.10；95%CI，0.95-1.27），前列腺癌（风险比=1.00；95%CI，0.93-1.08），泌尿器官癌（风险比=1.01；95%CI，0.90-1.14），NMSC（风险比=1.06；95%CI，1.02-1.10），以及恶性黑色素瘤（风险比=1.06；95%CI，0.95-1.17）。
除了维生素D水平较高时NMSC风险显著升高外，我们未发现维生素D水平与总体或特定癌症之间存在统计学上的显著关联。
我们的结果并未表明维生素D对总体癌症发病率有影响。
