Department of Otorhinolaryngology Head and Neck Surgery, Molecular and Cellular Oncology, University Medical Center, 55131 Mainz, Germany.
Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Int J Mol Sci. 2023 Oct 11;24(20):15058. doi: 10.3390/ijms242015058.
OPMDs (oral potentially malignant disorders) are a group of disorders affecting the oral mucosa that are characterized by aberrant cell proliferation and a higher risk of malignant transformation. Vitamin D (VitD) and its receptor (VDR) have been extensively studied for their potential contributions to the prevention and therapeutic management of various diseases and neoplastic conditions, including oral cancer. Observational studies suggest correlations between VitD deficiency and higher cancer risk, worse prognosis, and increased mortality rates. Interestingly, emerging data also suggest a link between VitD insufficiency and the onset or progression of OPMDs. Understanding the role of the VitD-VDR axis not only in established oral tumors but also in OPMDs might thus enable early detection and prevention of malignant transformation. With this article, we want to provide an overview of current knowledge about OPMDs and VitD and investigate their potential association and ramifications for clinical management of OPMDs.
口腔潜在恶性疾病（OPMDs）是一组影响口腔黏膜的疾病，其特征是异常细胞增殖和恶性转化的风险较高。维生素 D（VitD）及其受体（VDR）已被广泛研究，以探讨其在预防和治疗各种疾病和肿瘤性疾病中的作用，包括口腔癌。观察性研究表明，VitD 缺乏与癌症风险增加、预后更差和死亡率增加之间存在相关性。有趣的是，新出现的数据还表明 VitD 不足与 OPMDs 的发生或进展之间存在联系。因此，了解 VitD-VDR 轴不仅在已确立的口腔肿瘤中，而且在 OPMDs 中的作用，可能有助于早期发现和预防恶性转化。本文旨在概述 OPMDs 和 VitD 的现有知识，并探讨它们之间的潜在关联及其对 OPMDs 临床管理的影响。
