Chen Xiaojun, Egger Jan
Institute of Biomedical Manufacturing and Life Quality Engineering, School of Mechanical engineering, Shanghai Jiao Tong University, Dong Chuan Road 800, Shanghai, Post Code: 200240 China.
Department of Medicine, University Hospital of Giessen and Marburg (UKGM), Baldingerstraße, Marburg, 35043 Germany.
Springerplus. 2014 Mar 31;3:167. doi: 10.1186/2193-1801-3-167. eCollection 2014.
In 2010, gynecologic malignancies were the 4th leading cause of death in U.S. women and for patients with extensive primary or recurrent disease, treatment with interstitial brachytherapy may be an option. However, brachytherapy requires precise insertion of hollow catheters with introducers into the tumor in order to eradicate the cancer. In this study, a software solution to assist interstitial gynecologic brachytherapy has been investigated and the software has been realized as an own module under (3D) Slicer, which is a free open source software platform for (translational) biomedical research. The developed research module allows on-time processing of intra-operative magnetic resonance imaging (iMRI) data over a direct DICOM connection to a MR scanner. Afterwards follows a multi-stage registration of CAD models of the medical brachytherapy devices (template, obturator) to the patient's MR images, enabling the virtual placement of interstitial needles to assist the physician during the intervention.
2010年，妇科恶性肿瘤是美国女性第四大死因，对于患有广泛原发性或复发性疾病的患者，间质近距离放射治疗可能是一种选择。然而，近距离放射治疗需要将带有导入器的空心导管精确插入肿瘤以根除癌症。在本研究中，对一种辅助间质妇科近距离放射治疗的软件解决方案进行了研究，该软件已作为一个独立模块在（3D）Slicer下实现，（3D）Slicer是一个用于（转化）生物医学研究的免费开源软件平台。开发的研究模块允许通过与MR扫描仪的直接DICOM连接对术中磁共振成像（iMRI）数据进行实时处理。随后是将医用近距离放射治疗设备（模板、闭孔器）的CAD模型与患者的MR图像进行多阶段配准，从而能够在干预过程中虚拟放置间质针以协助医生。
