Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Irapuato, México.
Front Chem. 2014 Jan 10;1:42. doi: 10.3389/fchem.2013.00042. eCollection 2013.
Fungi, as well as the rest of living organisms must deal with environmental challenges such as stressful stimuli. Fungi are excellent models to study the general mechanisms of the response to stress, because of their simple, but conserved, signal-transduction and metabolic pathways that are often equivalent to those present in other eukaryotic systems. A factor that has been demonstrated to be involved in these responses is polyamine metabolism, essentially of the three most common polyamines: putrescine, spermidine and spermine. The gathered evidences on this subject suggest that polyamines are able to control cellular signal transduction, as well as to modulate protein-protein interactions. In the present review, we will address the recent advances on the study of fungal metabolism of polyamines, ranging from mutant characterization to potential mechanism of action during different kinds of stress in selected fungal models.
真菌与其他生物体一样，必须应对环境挑战，如应激刺激。真菌是研究应激反应一般机制的极佳模型，因为它们的信号转导和代谢途径简单但保守，通常与其他真核系统中的途径相当。已证明参与这些反应的一个因素是多胺代谢，主要是三种最常见的多胺：腐胺、亚精胺和精胺。关于这个主题的综合证据表明，多胺能够控制细胞信号转导，并调节蛋白质-蛋白质相互作用。在本综述中，我们将介绍真菌多胺代谢研究的最新进展，从突变体特征到选定真菌模型在不同类型应激下的潜在作用机制。
