Colombani M, Sansonetti N, Lepage V, Raffoux C, Colombani J
Institut d'Hématologie, Université Paris VII, Hôpital Saint-Louis, France.
Tissue Antigens. 1989 Jul;34(1):35-8. doi: 10.1111/j.1399-0039.1989.tb01715.x.
A serum from a patient (LAR), immunized by pregnancies and blood transfusions, reacted with cells carrying HLA-DR2 and/or -DR7 specificities (titer 1:200-1:1000). Absorption-elution experiments showed that the allo-serum recognized a determinant shared by DR2 and DR7 cells. The high correlation coefficients (0.90-1) with these specificities suggested that the supertypic specificity LAR was carried by the first DR molecule encoded by DRB1 gene. LAR is another example of new supertypic specificities, reflecting structural homologies between alleles at HLA class II loci.
一名因多次妊娠和输血而产生免疫的患者（LAR）的血清，与携带HLA - DR2和/或 - DR7特异性的细胞发生反应（滴度为1:200 - 1:1000）。吸收 - 洗脱实验表明，同种血清识别出DR2和DR7细胞共有的一个决定簇。与这些特异性的高相关系数（0.90 - 1）表明，超型特异性LAR由DRB1基因编码的第一个DR分子携带。LAR是新的超型特异性的另一个例子，反映了HLA II类基因座等位基因之间的结构同源性。
