Almarri A, Batchelor J R
Department of Clinical Laboratory and Pathology, Hamad Hospital, Doha, Qatar.
Lancet. 1994 Oct 29;344(8931):1194-5. doi: 10.1016/s0140-6736(94)90510-x.
The mechanism underlying the development of chronic infection with hepatitis B virus is not known. We have done two independent studies in Qatar, where such infection is common, to determine whether immunity to this virus is influenced by the HLA phenotype of an individual. The first study generated a hypothesis to test in the second. In both studies, there was a significant deficiency of HLA-DR2 and an excess of HLA-DR7 in patients with chronic persistent infection with hepatitis B virus. We conclude that HLA phenotype is one of the factors influencing the response to infection with this virus.
乙型肝炎病毒慢性感染的发病机制尚不清楚。我们在卡塔尔进行了两项独立研究，该国这种感染很常见，目的是确定个体的HLA表型是否会影响对该病毒的免疫。第一项研究提出了一个假设，以便在第二项研究中进行检验。在两项研究中，慢性持续性乙型肝炎病毒感染患者中HLA - DR2显著缺乏，而HLA - DR7则过多。我们得出结论，HLA表型是影响对该病毒感染反应的因素之一。
