抗精神病药物与代谢紊乱关联背后的药理机制。
Pharmacological mechanisms underlying the association of antipsychotics with metabolic disorders.
作者信息
Miron Ileana Cristina, Baroană Victoriţa Cătălina, Popescu Florica, Ionică Floriana
机构信息
Ph.D. Student in Pharmacology, University of Medicine and Pharmacy of Craiova.
Pharmacology Discipline, Faculty of Medicine, University of Medicine and Pharmacy of Craiova.
出版信息
Curr Health Sci J. 2014 Jan;40(1):12-7. doi: 10.12865/CHSJ.40.01.02. Epub 2013 Dec 29.
Abstract
Obesity and metabolic syndrome in association with an increased risk of cardiovascular disease and type II diabetes are significant problems that contribute to lower life expectancy of patients with schizophrenia. Understanding the pharmacological mechanisms of the current antipsychotic treatment is clearly the key to the improvement of pharmacotherapy, to avoid or to mitigate the metabolic adverse effects.
摘要
肥胖和代谢综合征与心血管疾病和II型糖尿病风险增加相关，是导致精神分裂症患者预期寿命降低的重要问题。明确当前抗精神病药物治疗的药理机制显然是改善药物治疗、避免或减轻代谢不良反应的关键。
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