Zimmermann S, Betticher D
Rev Med Suisse. 2014 Apr 9;10(425):788, 790-3.
Multiple new cancer drugs have been marketed during the last decade, and among those many molecularly targeted agents. Their impact on clinical outcomes population-wide remains hard to measure. Are we merely seeing the development of expensive and toxic drugs that benefit a minority of patients, or are battles actually won in the war on cancer? Both epidemiologic trends and clinical trial data show that a patient's outcome today is significantly better than 10 or 20 years ago, in terms of cure rates and survival time for advanced disease.
在过去十年间,多种新型抗癌药物已投放市场,其中有许多是分子靶向药物。它们对全体人群临床疗效的影响仍难以衡量。我们仅仅是看到了昂贵且有毒的药物的研发,这些药物仅使少数患者受益,还是在抗癌战争中确实取得了胜利呢?流行病学趋势和临床试验数据均表明,如今患者在治愈率和晚期疾病存活时间方面的预后明显优于10年或20年前。