Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Clin Pharmacol Ther. 2014 Apr;95(4):341-6. doi: 10.1038/clpt.2014.15.
Cancer chemotherapy has transitioned from the use of cytotoxic drugs to the era of agents with an apparent selectivity for a cancer-specific target. The past decade has provided evidence that therapy with such agents can be curative in subsets of patients. It is anticipated that incorporation of pharmacological principles for novel therapeutics will result in further refinement of outcome measures as well as the discovery of new treatment modalities for multiple malignant diseases.
癌症化疗已经从使用细胞毒性药物过渡到了针对特定癌症靶点的药物时代。过去十年的证据表明，此类药物的治疗在某些患者亚群中可以达到治愈效果。预计将药理学原理应用于新型治疗方法将进一步完善疗效评估指标，并为多种恶性疾病发现新的治疗方法。
