Wang Lin-Yan, Tang Yu-Ping, Liu Xin, Ge Ya-Hui, Li Wei-Xia
Zhongguo Zhong Yao Za Zhi. 2013 Dec;38(24):4214-9.
Coptidis Rhizoma-Euodiae Fructus has been widely used for the treatment of digestive diseases since Song Dynasty, and therapeutic efficacy is very obvious. Modern research found that alkaloids are the main bio-active constituents, and some of their contents have striking difference after compatibility of the two herbs. The Chinese medicine pair (CMP) has extensive biological activities, such as the effect of gastrointestinal effect, anti-tumor, lowering the blood pressure and blood fat and so on. And some action mechanism of CMP also got partial demonstration. This paper mainly summarized the bio-active constituents, compatibility effects, action mechanism and clinical applications of the CMP, which can provide a basis for further research and development of the CMP.
黄连-吴茱萸药对自宋代以来就被广泛用于治疗消化系统疾病,治疗效果非常显著。现代研究发现生物碱是其主要生物活性成分,两药配伍后部分生物碱含量有显著差异。该中药药对具有广泛的生物学活性,如胃肠效应、抗肿瘤、降血压和血脂等作用。并且该中药药对的一些作用机制也得到了部分论证。本文主要综述了该中药药对的生物活性成分、配伍效应、作用机制及临床应用,可为该中药药对的进一步研发提供依据。