Motovilov A A, Guseva N G, Kuz'mina N N
Vestn Akad Med Nauk SSSR. 1989(7):50-6.
Antibodies (Ab) reacting with the myocardial sarcolemma (SL) and interstitial connective tissue (ICT) were determined in 1333 rheumatic disease (RD) patients and in 286 healthy subjects of various age using indirect immunofluorescence technique. The age-related levels of SL and ICT Ab are responsible for the heterogeneous immune response to SL and ICT antigens. The presence of SL Ab is characteristic for young patients, of ICT Ab, for older patients. Children are found to have ICT Ab more infrequently, Sl Ab are more common in rheumatism than in other rheumatic diseases. The higher inflammatory process activity is associated with a more frequent presence of SL Ab and rare ICT Ab in each age group. In RD patients, SL Ab are considered to be risk factor of cardiac disease development. The ICT antigen is found to incorporate alpha-galactose. The reasons for the absence of ICT Ab in the healthy young and in patients with maximum inflammation are discussed.
采用间接免疫荧光技术，对1333例风湿性疾病（RD）患者和286名不同年龄段的健康受试者进行检测，以确定与心肌肌膜（SL）和间质结缔组织（ICT）发生反应的抗体（Ab）。SL和ICT Ab的年龄相关水平导致对SL和ICT抗原的免疫反应存在异质性。SL Ab的存在是年轻患者的特征，ICT Ab则是老年患者的特征。发现儿童较少出现ICT Ab，SL Ab在风湿病中比在其他风湿性疾病中更常见。在每个年龄组中，较高的炎症过程活动与SL Ab更频繁出现和ICT Ab罕见有关。在RD患者中，SL Ab被认为是心脏疾病发展的危险因素。发现ICT抗原包含α-半乳糖。讨论了健康年轻人和炎症最严重患者中不存在ICT Ab的原因。
