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α-D-半乳糖对心肌间质结缔组织抗原的嗜异性抗体的抑制作用

[Inhibition by alpha-D-galactose of heterophilic antibodies against the antigens of the interstitial connective tissue of the myocardium].

作者信息

Danilova T A

出版信息

Biull Eksp Biol Med. 1986 May;101(5):596-8.

PMID:2423154
Abstract

The reaction of heterophile antibodies with interstitial connective tissue cells of bovine myocardium was inhibited with alpha-D-galactose. D-glucose, D-mannose, L-fucose, N-acetylgalactosamine and other monosaccharides demonstrated the lack of inhibitory activity. Disaccharide melibiose and trisaccharide raffinose containing terminal alpha-galactose also had an inhibitory effect on the reaction of sera with bovine myocardium. The results show that heterophile antibodies to heterophile bovine antigen revealed in rheumatic patients' sera differ from antibodies to I and i antigens and T-antibodies, whose specificity is associated with terminal beta-galactose. They also differ from other heterophile antibodies described earlier.

摘要

嗜异性抗体与牛心肌间质结缔组织细胞的反应可被α-D-半乳糖抑制。D-葡萄糖、D-甘露糖、L-岩藻糖、N-乙酰半乳糖胺及其他单糖均无抑制活性。含有末端α-半乳糖的二糖蜜二糖和三糖棉子糖对血清与牛心肌的反应也有抑制作用。结果表明,风湿性患者血清中所发现的针对嗜异性牛抗原的嗜异性抗体不同于针对I和i抗原以及T抗体的抗体,后者的特异性与末端β-半乳糖有关。它们也不同于先前描述的其他嗜异性抗体。

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