Regulation of the mitochondrial Ca(2+) uniporter by MICU1 and MICU2.
作者信息
Foskett J Kevin, Madesh Muniswamy
机构信息
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, United States; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, United States.
Department of Biochemistry and Center for Translational Medicine, Temple University, Philadelphia, PA 19140, United States.
出版信息
Biochem Biophys Res Commun. 2014 Jul 11;449(4):377-83. doi: 10.1016/j.bbrc.2014.04.146. Epub 2014 May 1.
Abstract
摘要
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本文引用的文献
1
MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity.MICU1 和 MICU2 通过对 MCU 活性施加相反的影响来精细调节线粒体 Ca2+ 单向转运体。
Mol Cell. 2014 Mar 6;53(5):726-37. doi: 10.1016/j.molcel.2014.01.013. Epub 2014 Feb 20.
2
Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake.MICU1 调节线粒体钙摄取的结构和机制见解。
EMBO J. 2014 Mar 18;33(6):594-604. doi: 10.1002/embj.201386523. Epub 2014 Feb 10.
3
MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.MICU1 和 MICU2 在调控线粒体钙单向转运体中发挥非冗余作用。
EMBO Rep. 2014 Mar;15(3):299-307. doi: 10.1002/embr.201337946. Epub 2014 Feb 6.
4
Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.MICU1 功能丧失性突变导致一种脑-肌肉疾病，与线粒体钙信号的原发性改变有关。
Nat Genet. 2014 Feb;46(2):188-93. doi: 10.1038/ng.2851. Epub 2013 Dec 15.
5
MICU1 motifs define mitochondrial calcium uniporter binding and activity.MICU1 基序定义了线粒体钙单向转运体的结合和活性。
Cell Rep. 2013 Dec 26;5(6):1576-1588. doi: 10.1016/j.celrep.2013.11.026. Epub 2013 Dec 12.
6
Dynamics of mitochondrial Ca2+ uptake in MICU1-knockdown cells.MICU1 敲低细胞中线粒体钙摄取的动力学。
Biochem J. 2014 Feb 15;458(1):33-40. doi: 10.1042/BJ20131025.
7
EMRE is an essential component of the mitochondrial calcium uniporter complex.EMRE 是线粒体钙单向转运体复合物的必需组成部分。
Science. 2013 Dec 13;342(6164):1379-82. doi: 10.1126/science.1242993. Epub 2013 Nov 14.
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The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit.线粒体钙单向转运体是一种多聚体，可包含一个显性负性的孔形成亚基。
EMBO J. 2013 Aug 28;32(17):2362-76. doi: 10.1038/emboj.2013.157. Epub 2013 Jul 30.
9
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.MICU1 控制线粒体 Ca²⁺ 单向转运体的阈值和协同激活。
Cell Metab. 2013 Jun 4;17(6):976-987. doi: 10.1016/j.cmet.2013.04.020.
10
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.MICU2，MICU1 的同源物，位于线粒体单通道复合物内以调节钙处理。
PLoS One. 2013;8(2):e55785. doi: 10.1371/journal.pone.0055785. Epub 2013 Feb 7.
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