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Regulation of the mitochondrial Ca(2+) uniporter by MICU1 and MICU2.

作者信息

Foskett J Kevin, Madesh Muniswamy

机构信息

Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, United States; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, United States.

Department of Biochemistry and Center for Translational Medicine, Temple University, Philadelphia, PA 19140, United States.

出版信息

Biochem Biophys Res Commun. 2014 Jul 11;449(4):377-83. doi: 10.1016/j.bbrc.2014.04.146. Epub 2014 May 1.

Abstract
摘要

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本文引用的文献

1
MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity.
Mol Cell. 2014 Mar 6;53(5):726-37. doi: 10.1016/j.molcel.2014.01.013. Epub 2014 Feb 20.
2
Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake.
EMBO J. 2014 Mar 18;33(6):594-604. doi: 10.1002/embj.201386523. Epub 2014 Feb 10.
3
MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.
EMBO Rep. 2014 Mar;15(3):299-307. doi: 10.1002/embr.201337946. Epub 2014 Feb 6.
5
MICU1 motifs define mitochondrial calcium uniporter binding and activity.
Cell Rep. 2013 Dec 26;5(6):1576-1588. doi: 10.1016/j.celrep.2013.11.026. Epub 2013 Dec 12.
6
Dynamics of mitochondrial Ca2+ uptake in MICU1-knockdown cells.
Biochem J. 2014 Feb 15;458(1):33-40. doi: 10.1042/BJ20131025.
7
EMRE is an essential component of the mitochondrial calcium uniporter complex.
Science. 2013 Dec 13;342(6164):1379-82. doi: 10.1126/science.1242993. Epub 2013 Nov 14.
8
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit.
EMBO J. 2013 Aug 28;32(17):2362-76. doi: 10.1038/emboj.2013.157. Epub 2013 Jul 30.
9
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.
Cell Metab. 2013 Jun 4;17(6):976-987. doi: 10.1016/j.cmet.2013.04.020.
10
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.
PLoS One. 2013;8(2):e55785. doi: 10.1371/journal.pone.0055785. Epub 2013 Feb 7.

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