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Regulation of the mitochondrial Ca(2+) uniporter by MICU1 and MICU2.

作者信息

Foskett J Kevin, Madesh Muniswamy

机构信息

Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, United States; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, United States.

Department of Biochemistry and Center for Translational Medicine, Temple University, Philadelphia, PA 19140, United States.

出版信息

Biochem Biophys Res Commun. 2014 Jul 11;449(4):377-83. doi: 10.1016/j.bbrc.2014.04.146. Epub 2014 May 1.

DOI:10.1016/j.bbrc.2014.04.146

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5371403/

Abstract

摘要

相似文献

[1]

Regulation of the mitochondrial Ca(2+) uniporter by MICU1 and MICU2.

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[2]

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[3]

High-affinity cooperative Ca binding by MICU1-MICU2 serves as an on-off switch for the uniporter.

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[4]

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[5]

The crystal structure of MICU2 provides insight into Ca binding and MICU1-MICU2 heterodimer formation.

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[6]

Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca uptake.

Proc Natl Acad Sci U S A. 2020-8-14

[7]

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.

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[8]

The uniporter: from newly identified parts to function.

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[9]

The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter.

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[10]

Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism.

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引用本文的文献

[1]

Beyond the matrix: structural and physiological advancements in mitochondrial calcium signaling.

Biochem Soc Trans. 2023-4-26

[2]

The mechanism of MICU-dependent gating of the mitochondrial Cauniporter.

Elife. 2021-8-31

[3]

Structural characterization of the mitochondrial Ca uniporter provides insights into Ca uptake and regulation.

iScience. 2021-7-22

[4]

Mitochondrial Calcium Signaling in Pancreatic β-Cell.

Int J Mol Sci. 2021-3-3

[5]

Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU.

Life Sci Alliance. 2020-10

[6]

Redox regulation of ER and mitochondrial Ca signaling in cell survival and death.

Cell Calcium. 2019-2-16

[7]

Mesenchymal Stem Cells (MSCs) Coculture Protects [Ca] Orchestrated Oxidant Mediated Damage in Differentiated Neurons In Vitro.

Cells. 2018-12-6

[8]

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation.

Nat Commun. 2018-8-29

[9]

Mitochondrial Ca transport in the endothelium: regulation by ions, redox signalling and mechanical forces.

J R Soc Interface. 2017-12-13

[10]

High-affinity cooperative Ca binding by MICU1-MICU2 serves as an on-off switch for the uniporter.

EMBO Rep. 2017-8

本文引用的文献

[1]

MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity.

Mol Cell. 2014-2-20

[2]

Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake.

EMBO J. 2014-2-10

[3]

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.

EMBO Rep. 2014-2-6

[4]

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.

Nat Genet. 2013-12-15

[5]

MICU1 motifs define mitochondrial calcium uniporter binding and activity.

Cell Rep. 2013-12-12

[6]

Dynamics of mitochondrial Ca2+ uptake in MICU1-knockdown cells.

Biochem J. 2014-2-15

[7]

EMRE is an essential component of the mitochondrial calcium uniporter complex.

Science. 2013-11-14

[8]

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit.

EMBO J. 2013-7-30

[9]

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.

Cell Metab. 2013-6-4

[10]

MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.

PLoS One. 2013-2-7

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