Nestlé Research-EPFL Innovation Park, CH-1015 Lausanne, Switzerland.
Molecular Nutritional Medicine, Else Kröner Fresenius Center for Nutritional Medicine, Technische Universität München, 85354 Freising, Germany.
Int J Mol Sci. 2021 Mar 3;22(5):2515. doi: 10.3390/ijms22052515.
Accumulation of calcium in energized mitochondria of pancreatic β-cells is emerging as a crucial process for pancreatic β-cell function. β-cell mitochondria sense and shape calcium signals, linking the metabolism of glucose and other secretagogues to the generation of signals that promote insulin secretion during nutrient stimulation. Here, we describe the role of mitochondrial calcium signaling in pancreatic β-cell function. We report the latest pharmacological and genetic findings, including the first mitochondrial calcium-targeted intervention strategies developed to modulate pancreatic β-cell function and their potential relevance in the context of diabetes.
钙在胰腺 β 细胞的能量化线粒体中的积累，正逐渐成为胰腺 β 细胞功能的关键过程。β 细胞线粒体感知和塑造钙信号，将葡萄糖和其他分泌激动剂的代谢与促进营养刺激期间胰岛素分泌的信号生成联系起来。在这里，我们描述了线粒体钙信号在胰腺 β 细胞功能中的作用。我们报告了最新的药理学和遗传学发现，包括首次开发的靶向线粒体钙的干预策略，以调节胰腺 β 细胞功能及其在糖尿病背景下的潜在相关性。
