Gorynia Inge, Schwaiger Markus, Heinz Andreas
Klinik für Psychiatrie und Psychotherapie, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany,
Eur Arch Psychiatry Clin Neurosci. 2014 Dec;264(8):683-95. doi: 10.1007/s00406-014-0503-y. Epub 2014 May 4.
Based on the previous findings, it has been assumed that in schizophrenia patients, eye dominance and cannabis use will affect negative symptoms and intermanual coordination (IMC), an index of interhemispheric communication. But eye dominance, specifically the clinical findings for it, has been neglected in schizophrenia research. We therefore investigated its effects in 52 right-handed (36 right-eyed and 16 left-eyed) and 51 left-handed (35 left-eyed and 16 right-eyed) schizophrenia in-patients without and with drug use. Eye dominance affected IMC in all schizophrenia patients. When comparing right- and left-handers, we found that this result was only significant in the right-handed patients and in the smaller subgroup without drug use. In the right-handers, left eye dominance-like left-handedness-was associated with higher values in IMC and less pronounced manifestation of negative symptoms, right eye dominance was not. Thus, left-eyed right-handers may be more closely related to left-handers than to right-handers. In accordance with the results from the literature, we suggest that these findings are due to better interhemispheric connections and less impairment of white matter structures, especially in right-hemispheric regions. Moreover, cannabis use was related to higher scores in IMC and less pronounced negative symptoms, but only in the right-eyed and not in the left-eyed right-handers or in the left-handers. Hence, differences in eye dominance and handedness may be partially responsible for different results in interhemispheric connections among cannabis users. In conclusion, both eye dominance and use of cannabis should be taken into account when assessing clinical symptoms in schizophrenia patients.
基于先前的研究结果，人们认为在精神分裂症患者中，眼优势和大麻使用会影响阴性症状和双手协调（IMC），后者是半球间交流的一个指标。但是，眼优势，尤其是其临床研究结果，在精神分裂症研究中一直被忽视。因此，我们调查了52名右利手（36名右眼优势和16名左眼优势）和51名左利手（35名左眼优势和16名右眼优势）的精神分裂症住院患者，这些患者有无药物使用情况。眼优势影响了所有精神分裂症患者的双手协调。在比较右利手和左利手时，我们发现这一结果仅在右利手患者以及较小的未使用药物的亚组中显著。在右利手患者中，左眼优势——类似于左利手——与更高的双手协调值以及阴性症状表现不明显相关，而右眼优势则不然。因此，左眼优势的右利手可能与左利手的关系比与右利手的关系更密切。根据文献结果，我们认为这些发现是由于半球间连接更好以及白质结构损伤较少，尤其是在右半球区域。此外，大麻使用与更高的双手协调得分以及不明显的阴性症状相关，但仅在右眼优势的右利手患者中如此，在左眼优势的右利手患者或左利手患者中则不然。因此，眼优势和利手的差异可能部分导致了大麻使用者半球间连接的不同结果。总之，在评估精神分裂症患者的临床症状时，应同时考虑眼优势和大麻使用情况。
