Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité -Universitätsmedizin, Berlin, Germany.
Laterality. 2020 May;25(3):349-362. doi: 10.1080/1357650X.2019.1690497. Epub 2019 Nov 18.
Based on numerous findings of an abnormal laterality in schizophrenia disorder, we hypothesized that handedness and lateral preferences may affect the age at onset in schizophrenia patients. Two samples of schizophrenia patients, the first a sample of 34 right-handers and 42 left-handers and a replication set of 84 right-handers, were examined with regard to age at onset considering handedness and the four Luria's signs (arm folding, hand clasping, familial sinistrality and eye dominance) as well as gender. The association between these parameters and age at onset was investigated by means of multiple regression analysis. Our analyses revealed that right-handers with right arm folding and left-handers with left arm folding showed an early age at onset, while in the late age at onset the opposite preferences prevailed. Apart from arm folding, signs of ambilaterality, i.e., left eye dominance in right-handers and familial sinistrality in left-handers were additional predictors for an early age at onset. Remarkably, all observations found in the first right-handed sample were confirmed in the right-handed replication set. We conclude that among the many different factors specific lateral preferences should also be considered in assessing patients who are at risk of psychosis.
基于精神分裂症障碍中存在的大量侧性异常发现，我们假设利手和侧性偏好可能会影响精神分裂症患者的发病年龄。我们检查了两个精神分裂症患者样本，第一个样本包括 34 名右利手和 42 名左利手，以及一个 84 名右利手的复制样本，考虑了利手和 Luria 的四个迹象（手臂交叉、手紧握、家族性左利手和眼优势）以及性别。通过多元回归分析研究了这些参数与发病年龄之间的关系。我们的分析表明，右利手者手臂交叉，左利手者手臂交叉，发病年龄较早，而在发病年龄较晚时，相反的偏好占主导地位。除了手臂交叉之外，双侧性的迹象，即右利手者的左眼优势和左利手者的家族性左利手，也是发病年龄较早的额外预测指标。值得注意的是，在第一个右利手样本中发现的所有观察结果都在右利手复制样本中得到了证实。我们得出结论，在评估有患精神病风险的患者时，除了许多不同的因素外，还应考虑特定的侧性偏好。
