自然杀伤细胞亚群的衰老塑造。
Shaping of NK cell subsets by aging.
机构信息
Department of Immunology, IMIBIC - Reina Sofia University Hospital - University of Cordoba, REIPI, Cordoba, Spain.
Department of Immunology, IMIBIC - Reina Sofia University Hospital - University of Cordoba, REIPI, Cordoba, Spain.
出版信息
Curr Opin Immunol. 2014 Aug;29:56-61. doi: 10.1016/j.coi.2014.04.002. Epub 2014 May 8.
NK cells are key players in the innate immune response against virus infection and tumors. Here we describe the current knowledge on age-associated changes in NK cells and the role of persistent CMV infection in configuring NK cell compartment in the elderly. Aging but not CMV causes a redistribution of NK cell subsets as shown by a decrease of CD56bright cells and an increase of CD56-CD16+ NK cells. On the contrary the changes in CD56dimCD16+ NK cells are compatible with the accumulation of CD57+ long-lived NK cells that can also be observed in young CMV-seropositive individuals. NK cell function and dynamics in the elderly will be related not only with age but also with exposure to pathogens, especially CMV.
自然杀伤 (NK) 细胞是针对病毒感染和肿瘤的固有免疫反应的关键参与者。在这里，我们描述了与年龄相关的 NK 细胞变化以及持续性 CMV 感染在老年人群中配置 NK 细胞区室中的作用的现有知识。衰老而非 CMV 导致 NK 细胞亚群重新分布，表现为 CD56bright 细胞减少和 CD56-CD16+ NK 细胞增加。相反，CD56dimCD16+ NK 细胞的变化与 CD57+长寿 NK 细胞的积累一致，在年轻的 CMV 血清阳性个体中也可以观察到这种现象。老年人 NK 细胞的功能和动态不仅与年龄有关，还与病原体的暴露有关，特别是 CMV。
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