Baichwal R R, DeVries G H
Department of Biochemistry and Molecular Biophysics, Virginia Commonwealth University, Richmond 23298.
Biochem Biophys Res Commun. 1989 Oct 31;164(2):883-8. doi: 10.1016/0006-291x(89)91541-6.
Evidence is presented that a mitogen can be produced from myelin basic protein (MBP) which may be related to the Schwann cell proliferation characteristic of Wallerian degeneration. Myelin derived from the shiverer mutant which is devoid of MBP is also devoid of mitogenic activity. Absorption of the mitogen with a polyclonal antisera to MBP abolishes the mitogenic effect. In addition, only liposomes containing MBP are mitogenic to cultured Schwann cells; liposomes containing other myelin-specific proteins do not stimulate Schwann cell division. These results directly demonstrate the MBP origin of a mitogen for Schwann cells.
有证据表明，髓鞘碱性蛋白（MBP）可产生一种有丝分裂原，这可能与华勒氏变性中雪旺细胞增殖特性有关。来自缺乏MBP的颤抖突变体的髓鞘也缺乏有丝分裂活性。用针对MBP的多克隆抗血清吸收有丝分裂原可消除有丝分裂效应。此外，只有含有MBP的脂质体对培养的雪旺细胞有丝分裂原性；含有其他髓鞘特异性蛋白的脂质体不会刺激雪旺细胞分裂。这些结果直接证明了雪旺细胞有丝分裂原的MBP来源。
