Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Department of Acute Infectious Diseases Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
J Clin Virol. 2014 Jul;60(3):185-9. doi: 10.1016/j.jcv.2014.03.020. Epub 2014 Apr 13.
Severe fever with thrombocytopenia syndrome (SFTS) is a newly identified viral zoonosis caused by a phlebovirus. Most reported SFTS cases are farmers living in rural areas. The seroprevalence of SFTS virus in farmers has not been investigated. The current knowledge of SFTS virus seroprevalence in animals, especially in wild animals, is still poor.
To investigate SFTS virus seroprevalence among farmers and a variety of animal species.
SFTS virus antibodies in sera were determined using a double-antigen sandwich ELISA. Serum samples were collected from 2547 farmers and 2741 animals in 6 SFTS-endemic counties from March 2012 to February 2013 in Jiangsu province. The farmer participants aged from 15 to 90 years. All of them were interviewed using a structured questionnaire. The animals sampled included 6 domesticated animal species and 2 wild animal species.
SFTSV antibodies were found in a total of 33 farmers (1.30%) and was more prevalent in males than in females (respectively 1.87% and 0.71%, P<0.01). The mean age of seropositive farmers was 56.5 years and seroprevalence increased gradually with age. Seroprevalence in animal species were: goats (66.8%), cattle (28.2%), dogs (7.4%), pigs (4.7%), chickens (1.2%), geese (1.7%), rodents (4.4%) and hedgehogs (2.7%). Multiple variable logistic regression analysis showed that grazing, grass mowing, raising cattle, age, farm work time and tick bites were risk factors for SFTS virus infection among farmers.
SFTSV readily infects humans with farming-related exposures as well as numerous domestic and wild animals. Serological results further suggest that the virus circulates widely in Jiangsu province.
严重发热伴血小板减少综合征（SFTS）是一种由布尼亚病毒引起的新发病毒性人畜共患病。大多数报告的 SFTS 病例是居住在农村地区的农民。尚未调查农民中 SFTS 病毒的血清流行率。目前对动物，尤其是野生动物中 SFTS 病毒血清流行率的了解仍然很少。
调查农民和多种动物物种中 SFTS 病毒的血清流行率。
使用双抗原夹心 ELISA 法检测血清中的 SFTS 病毒抗体。2012 年 3 月至 2013 年 2 月，在江苏省 6 个 SFTS 流行县采集了 2547 名农民和 2741 只动物的血清样本。农民参与者年龄在 15 至 90 岁之间。所有参与者均使用结构化问卷进行访谈。采样的动物包括 6 种家养动物和 2 种野生动物。
共发现 33 名农民（1.30%）存在 SFTSV 抗体，男性的患病率高于女性（分别为 1.87%和 0.71%，P<0.01）。血清阳性农民的平均年龄为 56.5 岁，患病率随年龄逐渐增加。动物物种的血清流行率分别为：山羊（66.8%）、牛（28.2%）、狗（7.4%）、猪（4.7%）、鸡（1.2%）、鹅（1.7%）、啮齿动物（4.4%）和刺猬（2.7%）。多变量逻辑回归分析表明，放牧、割草、养牛、年龄、农场工作时间和蜱叮咬是农民感染 SFTS 病毒的危险因素。
SFTSV 容易感染与农业相关的暴露人群以及众多家养和野生动物。血清学结果进一步表明，该病毒在江苏省广泛传播。
