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男性生育力保存,2014年我们处于什么阶段?

Male fertility preservation, where are we in 2014?

作者信息

Goossens Ellen, Tournaye Herman

机构信息

Research group biology of testis, department of embryology and genetics, Vrije universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

Research group biology of testis, department of embryology and genetics, Vrije universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

出版信息

Ann Endocrinol (Paris). 2014 May;75(2):115-7. doi: 10.1016/j.ando.2014.03.011. Epub 2014 Apr 29.

DOI:10.1016/j.ando.2014.03.011
PMID:24793992
Abstract

Male fertility preservation receives growing attention in the field of reproductive medicine. The first clinical programs were established to preserve reproductive potential in men needing gonadotoxic treatment. Sperm cryopreservation is now a standard procedure. Since a few years, several centres offer testicular tissue cryopreservation to prepubertal boys. This method is still experimental and further research is needed to implement the transplantation techniques in the clinic. With the aim to preserve or restore fertility in patients affected by other diseases (Klinefelter syndrome, Sertoli cell only syndrome), techniques for in vitro spermatogenesis are being developed.

摘要

男性生育力保存在生殖医学领域受到越来越多的关注。首个临床项目旨在为需要接受性腺毒性治疗的男性保留生殖潜能。精子冷冻保存如今已是标准程序。近年来,多个中心为青春期前男孩提供睾丸组织冷冻保存服务。该方法仍处于实验阶段,需要进一步研究以便在临床中应用移植技术。为了在受其他疾病(克兰费尔特综合征、唯支持细胞综合征)影响的患者中保存或恢复生育力,体外精子发生技术正在研发中。

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Male fertility preservation, where are we in 2014?男性生育力保存,2014年我们处于什么阶段?
Ann Endocrinol (Paris). 2014 May;75(2):115-7. doi: 10.1016/j.ando.2014.03.011. Epub 2014 Apr 29.
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Testicular biopsy and cryopreservation for fertility preservation of prepubertal boys with Klinefelter syndrome: a pro/con debate.睾丸活检及冷冻保存用于克氏综合征青春期前男孩生育力保存:正反方辩论
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The feasibility of fertility preservation in adolescents with Klinefelter syndrome.青春期克莱恩费尔特综合征患者生育力保存的可行性。
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Spermatogonial stem cell preservation and transplantation: from research to clinic.精原干细胞保存与移植:从研究到临床。
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Assisted reproductive outcomes of male cancer survivors.男性癌症幸存者的辅助生殖结局。
J Cancer Surviv. 2015 Jun;9(2):208-14. doi: 10.1007/s11764-014-0398-7. Epub 2014 Oct 2.