Hutton Eileen K, Thorpe Julia
Department of Obstetrics and Gynecology, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada; Department of Midwifery Science, EMGO Institute for Health and Care Research, VU University Medical Center, VU University, Amsterdam, The Netherlands; Midwifery Education Program, Faculty of Health Sciences, McMaster University, 1280 Main Street West, MDCL 2210, Hamilton, Ontario L8S 4 K1, Canada.
Midwifery Education Program, Faculty of Health Sciences, McMaster University, 1280 Main Street West, MDCL 2210, Hamilton, Ontario L8S 4 K1, Canada.
Early Hum Dev. 2014 Jul;90(7):333-9. doi: 10.1016/j.earlhumdev.2014.04.005. Epub 2014 Apr 30.
Meconium stained amniotic fluid (MSAF) is common and associated with meconium aspiration syndrome (MAS). Other consequences of meconium passage before birth are less well understood.
We reviewed the literature for original papers reporting on outcomes associated with MSAF.
Among preterm infants MSAF is more prevalent than previously believed and is associated with higher neonatal morbidity. Intrauterine exposure to meconium is associated with inflammation of tissues of the lung, chorionic plate and umbilical vessels and through various mechanisms may contribute to neonatal morbidity, independent of MAS. No compelling evidence supported an association between MSAF and increased neurological impairment, including early seizure activity.
胎粪污染羊水（MSAF）很常见，且与胎粪吸入综合征（MAS）相关。出生前胎粪排出的其他后果尚不太清楚。
我们检索了文献中报告与MSAF相关结局的原始论文。
在早产儿中，MSAF比之前认为的更为普遍，且与更高的新生儿发病率相关。宫内暴露于胎粪与肺、绒毛膜板和脐血管组织的炎症相关，并且通过各种机制可能导致新生儿发病，独立于MAS。没有令人信服的证据支持MSAF与神经功能损害增加之间的关联，包括早期癫痫活动。
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