Chan Yujia A, Hieter Philip, Stirling Peter C
Michael Smith Laboratories, University of British Columbia, Vancouver, V6T 1Z4, Canada.
Michael Smith Laboratories, University of British Columbia, Vancouver, V6T 1Z4, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, V6T 1Z3, Canada.
Trends Genet. 2014 Jun;30(6):245-53. doi: 10.1016/j.tig.2014.03.005. Epub 2014 May 1.
The role of normal transcription and RNA processing in maintaining genome integrity is becoming increasingly appreciated in organisms ranging from bacteria to humans. Several mutations in RNA biogenesis factors have been implicated in human cancers, but the mechanisms and potential connections to tumor genome instability are not clear. Here, we discuss how RNA-processing defects could destabilize genomes through mutagenic R-loop structures and by altering expression of genes required for genome stability. A compelling body of evidence now suggests that researchers should be directly testing these mechanisms in models of human cancer.
从细菌到人类的各种生物体中，正常转录和RNA加工在维持基因组完整性方面的作用日益受到重视。RNA生物合成因子中的几种突变与人类癌症有关，但其中的机制以及与肿瘤基因组不稳定性的潜在联系尚不清楚。在这里，我们讨论RNA加工缺陷如何通过诱变R环结构以及改变基因组稳定性所需基因的表达来破坏基因组的稳定性。现在，大量令人信服的证据表明，研究人员应该在人类癌症模型中直接测试这些机制。
