Wickramasinghe Vihandha O, Venkitaraman Ashok R
Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.
Mol Cell. 2016 Feb 18;61(4):496-505. doi: 10.1016/j.molcel.2016.02.001.
It is emerging that the pathways that process newly transcribed RNA molecules also regulate the response to DNA damage at multiple levels. Here, we discuss recent insights into how RNA processing pathways participate in DNA damage recognition, signaling, and repair, selectively influence the expression of genome-stabilizing proteins, and resolve deleterious DNA/RNA hybrids (R-loops) formed during transcription and RNA processing. The importance of these pathways for the DNA damage response (DDR) is underscored by the growing appreciation that defects in these regulatory connections may be connected to the genome instability involved in several human diseases, including cancer.
新出现的情况是，处理新转录RNA分子的途径也在多个层面上调节对DNA损伤的反应。在这里，我们讨论了关于RNA加工途径如何参与DNA损伤识别、信号传导和修复，如何选择性地影响基因组稳定蛋白的表达，以及如何解决转录和RNA加工过程中形成的有害DNA/RNA杂交体（R环）的最新见解。这些途径对DNA损伤反应（DDR）的重要性因人们越来越认识到这些调节联系中的缺陷可能与包括癌症在内的几种人类疾病所涉及的基因组不稳定有关而得到强调。
