Nicotinamide in Friedreich's ataxia: useful or not?
作者信息
Lynch David R, Fischbeck Kenneth H
机构信息
Division of Neurology and Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
出版信息
Lancet. 2014 Aug 9;384(9942):474-5. doi: 10.1016/S0140-6736(14)60573-0. Epub 2014 Apr 30.
Abstract
摘要
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Increasing frataxin gene expression with histone deacetylase inhibitors as a therapeutic approach for Friedreich's ataxia.使用组蛋白去乙酰化酶抑制剂增加铁蛋白基因表达作为治疗弗里德里希共济失调的一种方法。
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