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对情绪图片的神经反应的遗传力:来自成年双胞胎样本中事件相关电位的证据。

Heritability of the neural response to emotional pictures: evidence from ERPs in an adult twin sample.

作者信息

Weinberg Anna, Venables Noah C, Proudfit Greg Hajcak, Patrick Christopher J

机构信息

Department of Psychology, Stony Brook University, Stony Brook, NY 11794-2500 and Department of Psychology, Florida State University, Tallahassee, FL 32306-4301, USA

Department of Psychology, Stony Brook University, Stony Brook, NY 11794-2500 and Department of Psychology, Florida State University, Tallahassee, FL 32306-4301, USA.

出版信息

Soc Cogn Affect Neurosci. 2015 Mar;10(3):424-34. doi: 10.1093/scan/nsu059. Epub 2014 May 1.

Abstract

Affect-modulated event-related potentials (ERPs) are increasingly used to study psychopathology and individual differences in emotion processing. Many have suggested that variation in these neural responses reflects genetically mediated risk. However, to date, no studies have demonstrated genetic contributions to affect-modulated ERPs. The present study therefore sought to examine the heritability of a range of ERPs elicited during affective picture viewing. One hundred and thirty monozygotic and 124 dizygotic twin pairs passively viewed 30 pleasant, 30 neutral and 30 unpleasant images for 6 s each. The early posterior negativity was scored for each subject; in addition, the P300/late positive potential (LPP) was scored in multiple time windows and sites. Results indicate that the centro-parietal P300 (occurring between 300 and 600 ms) is subject to substantial genetic contributions. Furthermore, variance in the P300 elicited by affective stimuli was moderately heritable even after controlling for the P300 elicited by neutral stimuli. Later and more frontal activation (i.e. between 1000 and 3000 ms) also showed evidence of heritablity. Early parietal, and perhaps later frontal portions of the P300/LPP complex, may therefore represent promising neurobehavioral markers of genetically influenced processing of emotional information.

摘要

情感调制的事件相关电位(ERP)越来越多地用于研究精神病理学和情绪加工中的个体差异。许多人认为,这些神经反应的变化反映了基因介导的风险。然而,迄今为止,尚无研究证明基因对情感调制ERP有贡献。因此,本研究旨在检验在观看情感图片期间诱发的一系列ERP的遗传性。130对同卵双胞胎和124对异卵双胞胎被动观看30张愉悦、30张中性和30张不愉快的图片,每张图片观看6秒。对每个受试者的早期后负波进行评分;此外,在多个时间窗口和部位对P300/晚期正电位(LPP)进行评分。结果表明,中央顶叶P300(出现在300至600毫秒之间)受到显著的基因影响。此外,即使在控制了中性刺激诱发的P300之后,情感刺激诱发的P300的变异仍具有中等遗传性。后期和更靠前的激活(即1000至3000毫秒之间)也显示出遗传性证据。因此,P300/LPP复合体早期的顶叶部分以及可能后期的额叶部分,可能代表了受基因影响的情绪信息加工的有前景的神经行为标记。

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