通过一维等电聚焦观察到的HLA - C位点抗原：迄今已知的HLA - C特异性及两种亚型的定义
HLA-C locus antigens seen by one-dimensional isoelectric focusing: definition of the so far known HLA-C specificities and of two subtypes.
作者信息
Hajek-Rosenmayr A, Jungl L, Stammler M, Kirnbauer M
机构信息
Institute for Blood Group Serology, Vienna, Austria.
出版信息
Hum Immunol. 1989 Dec;26(4):227-36. doi: 10.1016/0198-8859(89)90001-3.
A panel of homozygous typing cells was employed for biochemical definition of all known HLA-C locus antigens from Cw1 through Cw11. Each HLA-C antigen yielded, after precipitation with one of the monoclonal antibodies W6/32, 4E, or HC10, a specific banding pattern on one-dimensional isoelectric focusing gels. In addition, two biochemical subtypes of Cw1 and Cw7 could be identified. These biochemical HLA-C "splits" were characterized not only by different isoelectric points but also by strong linkage disequilibriums with certain HLA-B antigens.
使用一组纯合分型细胞对从Cw1到Cw11的所有已知HLA - C位点抗原进行生化定义。每种HLA - C抗原在用单克隆抗体W6/32、4E或HC10之一沉淀后，在一维等电聚焦凝胶上产生特定的条带模式。此外，还可鉴定出Cw1和Cw7的两种生化亚型。这些生化性的HLA - C“细分类型”不仅以不同的等电点为特征，而且与某些HLA - B抗原存在强连锁不平衡。
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