Koletzko Berthold, Kolacek Sanja, Phillips Alan, Troncone Riccardo, Vandenplas Yvan, Thapar Nikhil, Baumann Ulrich, van Goudoever Johannes, Mihatsch Walter, de Swarte Casper, Benninga Marc, Mearin Luisa
*Dr von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany †Children's Hospital Zagreb University Medical School, Zagreb, Croatia ‡UCL Institute of Child Health, London, UK §Department of Paediatrics, Universita degli Studi di Napoli Frederico II, Naples, Italy ||ESPGHAN Committee on Gastroenterology, Department of Paediatrics, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium ¶ESPGHAN Committee on Hepatology, Children's Hospital, Hannover Medical School, Hannover, Germany #ESPGHAN Committee on Nutrition, VU University Medical Center and Emma Children's Hospital, AMC, Amsterdam **Food &ThoughT, Den Haag ††Emma Children's Hospital, AMC, Amsterdam ‡‡Department of Paediatrics, Leids Universitair Medisch Centrum, Leiden, The Netherlands.
J Pediatr Gastroenterol Nutr. 2014 Aug;59(2):274-8. doi: 10.1097/MPG.0000000000000411.
Children comprise one-fifth of Europe's population. Promoting child health and development is of key importance for society and its future. This position paper highlights opportunities of investing in gastrointestinal, liver, and nutritional research to promote child health and delineates priorities for research. Investing in child health plays a key role in the promotion of population health, well-being, and disease prevention lifelong, with large health economic benefits. Major opportunities for improving knowledge and translational application arise from recent scientific and technological developments, for example, the long-term impact of early environmental cues interacting with genes. Personalised approaches to therapy and prevention should be enhanced. Deciphering the microbiome and its effects on functions can help in promoting long-term health. Epigenetic research can help to understand how early environmental factors influence later gastrointestinal and hepatic health and disease. A linked nutrition and physical activity strategy can promote health and prevent nutritional deficiencies, inactivity, and chronic noncommunicable diseases, such as diabetes, to ensure optimal health and cognition. Special attention should be devoted to populations with low socioeconomic status, migrant background, and ethnic minorities, and to critical life periods, including pregnancy, lactation, infancy, and childhood. Improved understanding of optimal nutrition and on maintaining gut and liver homeostasis throughout childhood will help prevent chronic diseases in later life.
儿童占欧洲人口的五分之一。促进儿童健康与发展对社会及其未来至关重要。本立场文件强调了投资于胃肠、肝脏和营养研究以促进儿童健康的机遇，并明确了研究重点。投资于儿童健康在促进人群健康、福祉以及终身疾病预防方面发挥着关键作用，具有巨大的健康经济效益。近期的科技发展带来了提升知识水平和转化应用的重大机遇，例如早期环境线索与基因相互作用的长期影响。应加强个性化的治疗和预防方法。解读微生物组及其对功能的影响有助于促进长期健康。表观遗传学研究有助于了解早期环境因素如何影响后期的胃肠和肝脏健康及疾病。将营养与体育活动相结合的策略能够促进健康，预防营养缺乏、缺乏运动以及慢性非传染性疾病（如糖尿病），以确保最佳的健康和认知状态。应特别关注社会经济地位较低、有移民背景和少数民族群体，以及包括怀孕、哺乳、婴儿期和儿童期在内的关键生命阶段。更好地理解最佳营养以及在儿童期维持肠道和肝脏内环境稳定将有助于预防晚年的慢性疾病。
